In neuroscience, the Golgi cell is an inhibitory interneuron found in the cerebellar granular lining. They were first identified as an obstacle by Ecclesiastes et al. in 1964. This is also the first example of an inhibitory feedback network, where interneuron inhibition is identified anatomically. These cells synapse into granular cell dendrites and unipolar brush cells. They receive excitatory input from mossy fibers, as well as synapses in granular cells, and parallel fibers, which are long granular cell axons. This circuit thus enables the feedback-forward inhibition and feedback of the granular cells.
The main synaptic made by these cells is synapse to mossy fibers - granular inflammatory exitatory cells in glomerulus. Glomerulus consists of mossy fiber terminals, granule cell dendrites, Golgi terminals and covered by glia coat. Golgi cells act by changing the synapse of mossy granules.
Golgi cells use GABA as their transmitter. The basal level of GABA produces a postsynaptic leak conductance by activating GABA-A alpha receptors containing 6 tons in granular cells. This high affinity receptor lies in both synapses and extrasindaps in granular cells. Synaptic receptors mediate phasic contractions, a duration of about 20-30ms whereas extracaported receptors mediate tonic inhibition of approximately 200ms, and are activated by synapse spills.
In addition GABA acts on a GABA-B receptor located presinaptically on a mossy fiber terminal. It inhibits mossy fibers generating EPSCs from granule cells with temperature and frequency dependent way. At high moss burning frequencies (10 Hz) there is no GABA effect acting on presynaptic GABA-B receptors on embossed EPSCs. However, at low (1 Hz) firing GABA has no effect on EPSC mediated through these presinaptic GABA-B receptors.
Video Golgi cell
References
Maps Golgi cell
External links
- NIF Search - Golgi Cell through the Neuroscience Information Framework
Source of the article : Wikipedia
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